PeptiDream and Ipsen Expand the Scope of Their Collaboration for Discovery of Peptide Drugs to Treat Serious Endocrinologic Disease

Regulatory News:

PeptiDream Inc., a Tokyo-based pharmaceutical company (PeptiDream, Tokyo: 4587), and Ipsen (Paris:IPN) (Euronext: IPN, ADR: IPSEY), a global specialty driven pharmaceutical group, today announced that they have expanded the scope of their April 2013 research collaboration and license option agreement to discover, evaluate, potentially develop and launch therapeutic peptides to treat serious medical conditions in areas of therapeutic focus for Ipsen. The existing collaboration, which combines PeptiDream’s proprietary Peptide Discovery Platform System (PDPS) with Ipsen’s expertise in peptide drug discovery and pharmaceutical R&D, will now be extended in scope to enable further therapeutic peptide candidates to enter R&D for additional serious endocrinologic disease.

The details of the financial terms of the expanded agreement are not disclosed but are based on those of the existing collaboration. In exchange for worldwide rights to each therapeutic peptide resulting from the collaboration, Ipsen will pay all R&D and commercialization costs. PeptiDream will receive royalties on worldwide sales; or have the right to opt-in at predefined stages to support Japan development costs of each new candidate for royalty free commercial rights in that territory. In the latter circumstance, PeptiDream would also forego royalty income for ex-Japan sales.

"This expanded partnership with Ipsen to discover novel therapeutic peptides for serious disease reinforces the positive collaborative relationship with Ipsen and further underlines the status of PeptiDream as a major force in therapeutic peptide discovery in the pharmaceutical industry worldwide”, said Patrick Reid, Ph.D., Chief Scientific Officer and Head of PeptiDream's discovery programs.

Claude Bertrand, Executive Vice president R&D, Chief Scientific Officer at Ipsen stated: «The extension of the Ipsen-PeptiDream relationship is an important step in our collaboration to discover novel highly-selective peptides targeting specific serious diseases, using the synergies of skills and competencies between both companies. Ipsen continues to reinforce its technological platform to remain at the cutting-edge of peptide research.”

About Peptidream
PeptiDream Inc. is a public (Tokyo Stock Exchange Mothers: 4587) biopharmaceutical company founded in 2006 employing our proprietary Peptide Discovery Platform System (PDPS), a state-of-the-art highly versatile peptide generation and selection platform which enables the production of highly diverse (trillions) non-standard peptide libraries with high efficiency, for the discovery and development of best-in-class and first-in-class peptide-based therapeutics. PeptiDream aspires to be a world leader in the discovery and development of novel highly functional peptide therapeutics to address unmet medical needs and improve the quality of life of patients worldwide. For further information please visit www.peptidream.com

About Ipsen
Ipsen is a global specialty-driven pharmaceutical company with total sales exceeding €1.2 billion in 2012. Ipsen’s ambition is to become a leader in specialty healthcare solutions for targeted debilitating diseases. Its development strategy is supported by 3 franchises: neurology, endocrinology and uro-oncology. Moreover, the Group has an active policy of partnerships. Ipsen's R&D is focused on its innovative and differentiated technological platforms, peptides and toxins. In 2012, R&D expenditure totalled close to €250 million, representing more than 20% of Group sales. The Group has close to 4,900 employees worldwide. Ipsen’s shares are traded on segment A of Euronext Paris (stock code: IPN, ISIN code: FR0010259150) and eligible to the "Service de Règlement Différé” ("SRD”). The Group is part of the SBF 120 index. Ipsen has implemented a Sponsored Level I American Depositary Receipt (ADR) program, which trade on the over-the-counter market in the United States under the symbol IPSEY. For more information on Ipsen, visit www.ipsen.com.

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