Northfield Laboratories Inc. Reports Fiscal 2008 Fourth Quarter and Year-End Financial Results Reminder to Shareholders

Northfield Laboratories Inc. (Nasdaq: NFLD) provided this reminder to shareholders: the Company filed its Annual Report on Form 10K, letter from the Chairman, and final Proxy Statement with the Securities Exchange Commission on August 14, 2008. These items are available on the Company’s website at www.northfieldlabs.com. For the fiscal year, Northfield reported a net loss of $20.4 million, or $.76 per share, compared with a net loss of $27.7 million, or $1.03 per share, for the prior fiscal year. The Company reported shareholders’ equity of $27.0 million, with $20.7 million in cash and marketable securities. Northfield reported a loss of $5.8 million, or $0.21 cents per share, for the fiscal fourth quarter, compared with a loss of $6.4 million, or $0.24 cents per share, for the corresponding period last year. The opinion of Northfield’s independent accountants, KPMG LLP, with respect to Northfield’s audited financial statements for the fiscal year ended May 31, 2008 included an explanatory paragraph regarding the continuation of the company as a going concern. Annual Meeting of Stockholders Northfield will hold its 2008 annual meeting of stockholders on Thursday, October 2, 2008, at 10:00 a.m., local time, at the Deer Path Inn, Lake Forest, Illinois. The entire meeting, including the official proceedings, the annual business update, and the question and answer session will be broadcast live on the Internet. Details will be provided approximately two weeks before the meeting date. About Northfield Laboratories and PolyHeme® Northfield Laboratories Inc. is a leader in developing an oxygen-carrying red blood cell substitute for the treatment of life-threatening hemoglobin levels, when an oxygen-carrying fluid is required and red blood cells are not available. Northfield's product, PolyHeme(R), is under clinical investigation as an oxygen-carrying red blood cell substitute. It is a solution of chemically modified human hemoglobin that requires no cross matching and is therefore compatible with all blood types. PolyHeme® has a shelf life in excess of 12 months. For further information, visit http://www.northfieldlabs.com. Forward Looking Statement This press release may contain forward-looking statements concerning, among other things, Northfield's future business plans and strategies and clinical and regulatory developments affecting our PolyHeme red blood cell substitute product. These forward-looking statements are identified by the use of such terms as "intends," "expects," "plans," "estimates," "anticipates," "should," "believes" and similar terms. These forward-looking statements involve inherent risks and uncertainties. Our actual results may therefore differ materially from those predicted by the forward-looking statements because of various factors and possible events, including our potential inability to regain compliance with applicable Nasdaq listing standards, the possibility that since the full data from our Phase III clinical trial have not been submitted to, or reviewed by, FDA, they may not be sufficient to demonstrate the safety or effectiveness of PolyHeme, our ability to successfully file a Biologics License Application, our ability to be granted priority review of our Biologics License Application, our ability to obtain FDA approval to market PolyHeme commercially, our need to obtain additional capital to finance our ongoing business operations and the construction of an expanded commercial-scale manufacturing facility, our ability to obtain adequate supplies of raw materials and to manufacture PolyHeme in commercial quantities, our ability to market PolyHeme successfully, the possibility that competitors will develop products that will render PolyHeme obsolete or non-competitive, our ability to protect our intellectual property rights, the outcome of a purported class action lawsuit as described in our most recently filed annual report on Form 10-K, the possibility that we may be subject to product liability claims and other legal actions, our dependency on a limited number of key personnel, the uncertainty of third party reimbursement for our product and other risks and uncertainties described from time to time in our periodic reports filed with the Securities and Exchange Commission, including our most recently filed annual report on Form 10-K. These forward-looking statements speak only as of the date of this press release. We do not undertake any obligation to update or publicly release any revisions to forward-looking statements to reflect events, circumstances or changes in expectations after the time such statement is made. All subsequent written and oral forward-looking statements attributable to Northfield or any person acting on our behalf are qualified by this cautionary statement.