12.06.2008 14:50:00

Aetna Shows Commitment to Patient Safety with 70 Percent Reduction in Refills of Duplicate Statin Prescriptions

Aetna (NYSE:AET) today announced the results of an internal study which show a 70 percent reduction in prescription duplication for members enrolled in its therapeutic duplication program. Launched in January 2007, the program is available to fully insured members taking the cholesterol-lowering statin class of medications and was designed to improve patient safety and reduce risk of serious side effects. Based on the results, Aetna has expanded the program to include additional drug classes. Therapeutic duplication (TD) can occur when two doctors are prescribing medications for the same patient. It can also occur when a doctor changes from one medication to another within the same therapeutic class, but the patient doesn’t discontinue the first medication. In either situation, the individual may end up taking two drugs with similar actions unnecessarily, which could lead to serious side effects. According to the publication, Age and Ageing, patients who had greater numbers of medications in the home were more likely to have therapeutic duplication. The condition is considered a risk factor associated with poor health outcomes.1 Aetna uses its claim system to help identify members who may be at risk of therapeutic duplication for specific medications and provides an alert to the pharmacist that a TD may be occurring. In those instances, their pharmacist may ask about the medications they are supposed to take. The pharmacist can then help determine whether both medications are necessary or whether one of the medications should be discontinued. Generally, individuals usually do not need two drugs from the same category to treat a medical condition. "We need to remind people that medication errors pose a serious risk and can result in visits to the hospital or ER,” said Mark Rubino, Chief Pharmacy Officer, Aetna Pharmacy Management. "The results we’ve seen with this program are proving that we are helping pharmacists and doctors protect members’ safety while helping to reduce medical costs.” Results showed over 4,800 incidents of possible therapeutic duplication were identified among Aetna members in the statin class. Of those, pharmacists avoided filling 3,500 duplicate prescriptions. By providing a participating pharmacists’ with broader access to safety information in real-time, Aetna can help pharmacists stop a potentially unnecessary or dangerous duplication before a prescription is filled. Statins have been associated with serious adverse reactions including elevated liver enzymes and rhabdomyolysis, a serious condition that can lead to acute kidney failure. These effects are more likely with high medication doses and increased serum statin concentrations. Given the success of the program, Aetna expanded the therapeutic duplication program to include the following drug classes: Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants Proton pump inhibitors used to treat ulcers "Triptan” drugs used to treat migraine headaches Aetna is one of the nation’s leading diversified health care benefits companies, serving approximately 37.3 million people with information and resources to help them make better informed decisions about their health care. Aetna offers a broad range of traditional and consumer-directed health insurance products and related services, including medical, pharmacy, dental, behavioral health, group life and disability plans, and medical management capabilities and health care management services for Medicaid plans. Our customers include employer groups, individuals, college students, part-time and hourly workers, health plans, governmental units, government-sponsored plans, labor groups and expatriates. www.aetna.com 1 Medication management at home: medication-related risk factors associated with poor health outcomes, Lene Sorensen, Julie A. Stokes, David M. Purdie, Michael Woodward and Michael S. Roberts

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